Several new biomarkers are being investigated to prostate specific antigen pdf the diagnosis of prostate cancer. It is independent of prostate volume,
Several new biomarkers are being investigated to prostate specific antigen pdf the diagnosis of prostate cancer. It is independent of prostate volume, whereas PSA is not. This means that it could be useful clinically for a patient for whom digital rectal examination and PSA suggest possible prostate cancer, but the first prostate biopsy returns a normal result.
These studies have so far produced conflicting results. PCA3 was discovered to be highly expressed by prostate cancer cells in 1999. Does PCA3 help identify clinically significant prostate cancer? PCA3: a molecular urine assay for predicting prostate biopsy outcome”. Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy”. PCA3 molecular urine assay for prostate cancer in men undergoing repeat biopsy”. Progensa PCA3 test for prostate cancer detection”.
PCA3 molecular urine assay correlates with prostate cancer tumor volume: implication in selecting candidates for active surveillance”. Detailed analysis of histopathological parameters in radical prostatectomy specimens and PCA3 urine test results”. PCA3 score before radical prostatectomy predicts extracapsular extension and tumor volume”. Soyoung Kim and Anand Basu.
Interpretation of the prostate cancer gene 3 in reference to the individual clinical background: implications for daily practice”. PCA3: from basic molecular science to the clinical lab”. Predicting prostate cancer risk through incorporation of prostate cancer gene 3″. PCA3 for a first-line diagnostic test”. A multicenter evaluation of the PCA3 molecular urine test: pre-analytical effects, analytical performance, and diagnostic accuracy”. The use of PCA3 in the diagnosis of prostate cancer”.